Author

Jaclyn J. Ho

OptiScan (United States)ORCID 0000-0001-9166-5953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alec Basil HeckertiD· 1 shared Amara Greer-ShortiD· 1 shared Ana BudaniD· 1 shared Anna Greenwood· 1 shared Annie Truong· 1 shared Arnold Tao· 1 shared Bruce R. ConkliniD· 1 shared Charlene Bashore· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperMolecular Biology

Alec Basil HeckertORCID

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3 papers

Recent·Most cited

Gene Therapy Mediates Therapeutic Improvement in Cardiac Hypertrophy and Survival in a Murine Model of MYBPC3-Associated Cardiomyopathy

Amara Greer-Short, Anna Greenwood, Elena C. Leon, Tawny Neal Qureshi, Konor von Kraut, Justin Wong, Jonathan H. Tsui, Christopher A. Reid, Ze Cheng, Emilee Easter, Jin Yang, Jaclyn J. Ho, Stephanie S. Steltzer, Ana Budan, Marie Cho, , Laura Marie Lombardi

This study demonstrates that AAV gene therapy with TN-201 restores MYBPC3 protein levels, reverses cardiac hypertrophy, and improves survival in a murine model of MYBPC3-associated HCM.

Nature Communications · Mar 4, 2025Peer-reviewedGenetics

WRN Inhibition Leads to its Chromatin-Associated Degradation Via the PIAS4-RNF4-p97/VCP Axis

Fernando Rodríguez-Pérez, Dean E. Natwick, Lauren Schiff, David Trombley McSwiggen, Alec Basil Heckert, Melina Huey, Huntly M. Morrison, Mandy Loo, Rafael G. Miranda, John Filbin, José Ortega, Kayla Van Buren, Danny Murnock, Arnold Tao, Renee Butler, , Stephen E. Basham

This study identifies a novel regulatory mechanism for WRN degradation via the PIAS4-RNF4-p97/VCP axis in MSI-H cancer cells using single molecule tracking and inhibitor screening.

Nature Communications · Jul 18, 2024Peer-reviewedMolecular Biology

Functional analysis of a common BAG3 allele associated with protection from heart failure

Juan A. Pérez-Bermejo, Luke M. Judge, Christina L Jensen, Kenneth Kun-yu Wu, Hannah L. Watry, Annie Truong, Jaclyn J. Ho, Matthew Carter, Wendy V. Runyon, Robyn M. Kaake, Ernst H. Pulido, Mohammad A. Mandegar, Danielle L. Swaney, Po-Lin So, Nevan J. Krogan, Bruce R. Conklin

This study investigates the functional impact of a BAG3 allele associated with reduced heart failure risk, showing it enhances cardiomyocyte stress resistance through altered protein interactions.

Nature Cardiovascular Research · Jun 26, 2023Peer-reviewedGenetics