John J Cole

The paper identifies differentially expressed genes in specific brain regions of germ-free mice, highlighting microbiome influence on brain gene expression and potential relevance to neurological disease.

Direct and indirect LPS injury in human donor lungs produce distinct 4 h proteomic programs; signature reversal favours SYK, CDK, HDAC, JAK/STAT and PI3K/AKT/mTOR pathway modulation.

This study shows that Helicobacter hepaticus colonization protects against DSS colitis by promoting anti-inflammatory CD4+ T cell responses.

This study shows that peripheral inflammation triggers fat pad atrophy and lymph node expansion via macrophage activity, supporting immune response energy needs.

The paper shows that lung structural cells retain an inflammatory imprint after influenza infection, enabling faster viral control upon re-challenge.

This study investigates neuroinflammation in mice driven by TLR7 activation, finding global immune activation and region-specific neuronal gene expression changes in mood-related brain areas.

This study identifies thalamostriatal circuit disruption as a conserved neuroinflammatory mechanism linking systemic inflammation to depression and anhedonia in humans and mice.

The paper identifies novel therapeutic targets for AIEC infection by stratifying macrophages based on bacterial load and showing that targeting these pathways reduces AIEC replication.