Restoration of ovarian endocrine function with encapsulated immune isolated human ovarian xenograft in ovariectomized mice
Margaret A. Brunette, Monica A. Rionda, Delaney S Sinko, Jordan H. Machlin, Gabrielle M. Blevins, Marisa Leo, Ansen Tan, Bipasha Ray, Marília Cascalho, Vasantha Padmanabhan, Ariella Shikanov
This study shows that encapsulated human ovarian xenografts restore endocrine function in ovariectomized mice, integrating with the host's hypothalamus-pituitary-gonad axis and maintaining cyclicity and hormone levels.
Science Advances · Jan 1, 2026Peer-reviewedBioengineering