Ariella Shikanov

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

This study develops granular hydrogel composites (GHCs) that enable rapid revascularization of tissue grafts by promoting vascular network formation and integration with host vasculature.

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

This paper introduces a step-emulsion platform for scalable microgel fabrication that is robust, user-agnostic, and compatible with various materials and viscosities.

This paper develops microporous immune-isolating capsules that restore dynamic hormone signaling in a mouse model of premature ovarian insufficiency by enabling size-selective diffusion of hormones.

This paper validates a CUBIC-based workflow for volumetric analysis of follicles and vasculature in human ovarian tissue, showing comparable follicle density to histology and detailed vascular morphometrics.

This study shows that encapsulated human ovarian xenografts restore endocrine function in ovariectomized mice, integrating with the host's hypothalamus-pituitary-gonad axis and maintaining cyclicity and hormone levels.

This study shows that MAP hydrogel encapsulation improves revascularization and endocrine function of transplanted ovarian tissue in a mouse model of primary ovarian insufficiency.

This study transplants different-sex gonads into adult mice to assess their integration into the HPG axis, finding gonad- and sex-dependent gene expression patterns and steroidogenesis.

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

This study examines the transcriptomic and proteomic changes in cultured ovarian follicles, identifying gene expression patterns and differentially expressed genes between group culture conditions.

The paper analyzes single-oocyte RNA sequencing data from early-stage human follicles to identify differentially expressed genes between primordial and transitioning stages.

This study shows that 3D PEG hydrogels improve bovine preantral follicle growth compared to 2D culture, and bESCs can differentiate into gonadal somatic cell precursors.

This study examines how puberty suppression and testosterone affect Achilles tendon and enthesis properties in a mouse model of transmasculine gender-affirming hormone therapy, finding improved load capacity and increased cell density with GnRHa treatment.

This paper presents a single-cell RNA sequencing atlas of the human uterus, identifying 39 cell subtypes and proposing a consensus annotation system, while highlighting dynamic changes and potential progenitor cells across menstrual cycle phases.

This study uses scRNA-seq to identify cellular heterogeneity in human fallopian tubes, revealing distinct cell types and changes in disease states.