Vasantha Padmanabhan

This paper develops microporous immune-isolating capsules that restore dynamic hormone signaling in a mouse model of premature ovarian insufficiency by enabling size-selective diffusion of hormones.

This study shows that low-level chemical exposure during pregnancy in sheep leads to sex-specific, heritable DNA methylation changes across generations, with some effects persisting in unexposed descendants.

This study shows that encapsulated human ovarian xenografts restore endocrine function in ovariectomized mice, integrating with the host's hypothalamus-pituitary-gonad axis and maintaining cyclicity and hormone levels.

This study shows that MAP hydrogel encapsulation improves revascularization and endocrine function of transplanted ovarian tissue in a mouse model of primary ovarian insufficiency.

This study transplants different-sex gonads into adult mice to assess their integration into the HPG axis, finding gonad- and sex-dependent gene expression patterns and steroidogenesis.

This study examines the transcriptomic and proteomic changes in cultured ovarian follicles, identifying gene expression patterns and differentially expressed genes between group culture conditions.

The paper analyzes single-oocyte RNA sequencing data from early-stage human follicles to identify differentially expressed genes between primordial and transitioning stages.

This study examines how puberty suppression and testosterone affect Achilles tendon and enthesis properties in a mouse model of transmasculine gender-affirming hormone therapy, finding improved load capacity and increased cell density with GnRHa treatment.

The paper develops a DNA methylation reference panel for placental tissues to estimate cell composition from bulk DNAm data, showing improved performance over existing methods.

The paper deconvolves placental gene expression data to show cell type proportions drive preeclampsia gene expression differences, reducing differentially expressed genes after adjustment.