Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
Ruilin Tian, Anthony Abarientos, Jason Y. Hong, Sayed Hadi Hashemi, Rui Yan, Nina M. Dräger, Kun Leng, Mike A. Nalls, Andrew Singleton, Ke Xu, Faraz Faghri, Martin Kampmann
The paper performs genome-wide CRISPRi/a screens in human neurons to identify gene functions related to oxidative stress and neurodegenerative diseases, finding that lysosomal failure links to ferroptosis.
Nature Neuroscience · May 24, 2021Peer-reviewedGenomics