Rui Yan

The paper compares human, mouse, and chick foreguts to show human foregut combines mouse-like molecular patterning with chick-like epithelial architecture, suggesting chick embryos are useful for studying human foregut malformations.

This study identifies Fgf10 as a Pitx2-sensitive signal that drives asymmetric lung growth by modulating epithelial proliferation during early lung development.

This study identifies a biomechanical mechanism involving mesenchymal forces and SHH signaling that drives epithelial tube splitting during tracheal-esophageal separation in embryos.

ExSPM reveals spatiotemporal heterogeneities in lipid droplet polarity, showing dynamics and pathway-specific kinetics of lipid metabolism.

This study introduces pc-SMdM, a super-resolution technique to map nanoscale diffusivity on cellular membranes, revealing clusters influenced by cholesterol and membrane structure.

The paper performs genome-wide CRISPRi/a screens in human neurons to identify gene functions related to oxidative stress and neurodegenerative diseases, finding that lysosomal failure links to ferroptosis.