Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia
Lisa Bast, Shuyang Yao, José A. Martínez‐López, Fatima Memic, Hayley French, Milda Valiukonyte, Robert Karlsson, Jia Wen, Jie Song, Ruyue Zhang, Anthony Abrantes, Frank Koopmans, Anne‐May Österholm, Gorazd B. Rosoklija, J. John Mann, , Jens Hjerling‐Leffler
This study integrates genetic analysis with single nucleus RNA-seq to identify cell-type specific transcriptomic perturbations in schizophrenia, highlighting mitochondrial dysfunction and protein modification as key factors.
medRxiv · Mar 14, 2025 · PreprintGenetic & Genomic Medicine