Andrew J. Dwork

The paper measures 5-methyl-cytosine and 5-hydroxymethyl-cytosine in human neurons across the lifespan, showing dynamic changes in hmC linked to transcription, chromatin state, and sex-specific gene regulation.

The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.

The paper creates a brain-wide map of mitochondrial phenotypes by combining physical voxelization with biochemical profiling, revealing regional differences in mitochondrial density and function.

This study integrates genetic analysis with single nucleus RNA-seq to identify cell-type specific transcriptomic perturbations in schizophrenia, highlighting mitochondrial dysfunction and protein modification as key factors.

This paper introduces a cost-effective, scalable light sheet microscopy framework for high-resolution imaging of living and cleared samples, demonstrating its application on various biological samples.

This paper introduces spatial-ATAC-seq, a method for spatially resolved chromatin accessibility profiling at the cellular level, and demonstrates its application in mouse embryos and human tonsil tissue.

The paper demonstrates D2R-A2AR proximity in human ventral striatum using PLA and a Bayesian classifier, supporting their potential formation of heteromers.

The paper identifies brain-derived circulating cell-free DNA as a peripheral biomarker specific to cell-type and brain-region origins in neurotrauma and neurodegeneration.

The paper investigates the association between BDNF Val66Met polymorphism and brain BDNF levels with major depression and suicide, finding lower BDNF levels in depressed individuals and those with early life adversity.