Robert Karlsson

Atypical energy-related symptoms define biologically distinct subtypes of major depressive disorder

The paper identifies biologically distinct subtypes of MDD based on energy-related symptoms and finds genetic and metabolic differences between them.

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia

This study integrates genetic analysis with single nucleus RNA-seq to identify cell-type specific transcriptomic perturbations in schizophrenia, highlighting mitochondrial dysfunction and protein modification as key factors.

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

This study identifies genetic signals associated with age at menarche, highlights genes involved in pubertal development, and links reproductive timing to later life disease risk.

Comprehensive longitudinal study of epigenetic mutations in aging

This study examines the accumulation of epigenetic mutations with age using longitudinal blood samples and identifies factors influencing their occurrence.

RICOPILI: Rapid Imputation for COnsortias PIpeLIne

RICOPILI is a Perl-based pipeline for efficient GWAS analysis, including quality control, imputation, and meta-analysis, with automated parallelization for rapid data processing.

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

Copy number variation and neurodevelopmental problems in females and males in the general population

This study investigates the association between rare copy number variants (CNVs) and neurodevelopmental problems (NPs) in children, finding sex-specific effects in anxiety/depression.

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

This study identifies age-related DNA methylation changes in old Swedish twins over 20 years, showing stability across cohorts and genetic influences independent of age.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology

This study evaluates ADHD genetic risk variants' association with general psychopathology and specific neurodevelopmental traits, finding general pleiotropy and a specific link to hyperactivity/impulsivity.

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

SweGen: A whole-genome map of genetic variability in a cross-section of the Swedish population

SweGen provides a high-quality whole-genome map of genetic variation in the Swedish population, useful for clinical genetics and association studies.