J. John Mann

External validation and time-stability analysis of STARE, a blood-free quantification tool for irreversible PET tracers

The paper validates STARE, a blood-free PET quantification tool, showing high correlation with standard methods and time-stability across different scanners.

A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity

The paper creates a brain-wide map of mitochondrial phenotypes by combining physical voxelization with biochemical profiling, revealing regional differences in mitochondrial density and function.

Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia

This study integrates genetic analysis with single nucleus RNA-seq to identify cell-type specific transcriptomic perturbations in schizophrenia, highlighting mitochondrial dysfunction and protein modification as key factors.

PET Imaging of the Serotonin 1A Receptor in Major Depressive Disorder: Hierarchical Multivariate Analysis of 11CWAY100635 Overcomes Outcome Measure Discrepancies

This study applies hierarchical multivariate analysis to PET data of the serotonin 1A receptor in MDD, showing consistent results across outcome measures and pharmacokinetic models.

Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular level

This paper introduces spatial-ATAC-seq, a method for spatially resolved chromatin accessibility profiling at the cellular level, and demonstrates its application in mouse embryos and human tonsil tissue.

The contribution of genetic risk to the comorbidity of depression and anxiety: a multi-site electronic health records study

This study evaluates the association of genetic risk scores with depression and anxiety diagnoses, finding distinct genetic contributions to their comorbidity.

Source-to-Target Automatic Rotating Estimation (STARE) -- A publicly-available, blood-free quantification approach for PET tracers with irreversible kinetics: Theoretical framework and validation for FDG

The paper introduces STARE, a blood-free method for quantifying PET tracer influx rates without arterial blood sampling, validated using [18F]FDG PET data.

Early Life Adversity, but not suicide, is associated with less prefrontal cortex gray matter in adulthood

The paper examines the association between early life adversity and prefrontal cortex structure in adulthood, finding reduced cortical thickness and increased glial density linked to ELA, but not suicide.

Association of BDNF Val66Met Polymorphism and Brain BDNF levels with Major Depression and Suicide

The paper investigates the association between BDNF Val66Met polymorphism and brain BDNF levels with major depression and suicide, finding lower BDNF levels in depressed individuals and those with early life adversity.