Balanced Permeability Index is a Strong Predictor of Intestinal Absorption and Oral Bioavailability for Heterobifunctional Ligand-Directed Degraders
Javier L. Baylon, Matthew J. Chalkley, Tony Siu, Wilson Z. Shou, Yongnian Sun, Xianmei Cai, Anthony Paiva, Shivani Anil Patel, Tatyana A. Zvyaga, Dahlia R. Weiss
This study introduces BPILDD, a new metric combining size, polarity, lipophilicity, and cross-sectional area, to predict oral bioavailability of ligand-directed degraders more effectively than existing methods.
bioRxiv · Mar 19, 2025 · PreprintPharmacology & Toxicology