Pharmacology & ToxicologybioRxivPreprint
Balanced Permeability Index is a Strong Predictor of Intestinal Absorption and Oral Bioavailability for Heterobifunctional Ligand-Directed Degraders
Javier L. Baylon, Matthew J. Chalkley, Tony Siu…·Dahlia R. Weiss
This study introduces BPILDD, a new metric combining size, polarity, lipophilicity, and cross-sectional area, to predict oral bioavailability of ligand-directed degraders more effectively than existing methods.