Dahlia R. Weiss

Bexobrutideg is a BTK degrader that overcomes inhibitor resistance and suppresses autoimmune disease by catalytically degrading BTK.

This study introduces BPILDD, a new metric combining size, polarity, lipophilicity, and cross-sectional area, to predict oral bioavailability of ligand-directed degraders more effectively than existing methods.

This study uses protein frustration analysis to identify key residues distinguishing strong from weak BRD4-Cereblon degraders.

This study introduces the Balanced Permeability Index (BPI), a multi-parameter metric that improves classification of molecular permeability and efflux, outperforming individual physicochemical properties.