Author

Matthew J. Chalkley

Bristol-Myers Squibb (United States)ORCID 0000-0002-0484-7335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Anthony Paiva· 1 shared Dahlia R. WeissiD· 1 shared Javier L. BayloniD· 1 shared Shivani Anil PateliD· 1 shared Tatyana A. Zvyaga· 1 shared Tony SiuiD· 1 shared Wilson Z. ShouiD· 1 shared Xianmei CaiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

Anthony Paiva

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1 paper

Recent·Most cited

Balanced Permeability Index is a Strong Predictor of Intestinal Absorption and Oral Bioavailability for Heterobifunctional Ligand-Directed Degraders

Javier L. Baylon, Matthew J. Chalkley, Tony Siu, Wilson Z. Shou, Yongnian Sun, Xianmei Cai, Anthony Paiva, Shivani Anil Patel, Tatyana A. Zvyaga, Dahlia R. Weiss

This study introduces BPILDD, a new metric combining size, polarity, lipophilicity, and cross-sectional area, to predict oral bioavailability of ligand-directed degraders more effectively than existing methods.

bioRxiv · Mar 19, 2025 · PreprintPharmacology & Toxicology