Long non-coding RNAs as a novel source of beta cell autoantigens in type 1 diabetes
Jon Mentxaka, Aïsha Callebaut, Koldo García‐Etxebarria, Leire Bergara-Muguruza, Izei Pascual-González, Anthony R. Jones, Kedi Li, Henar Rojas Márquez, Ainara Castellanos–Rubio, Eddie A. James, Izortze Santín
This study identifies lncRNA-derived peptides that act as autoantigens in type 1 diabetes by activating CD4+ T cells through HLA-II restricted epitopes.
bioRxiv · Dec 2, 2025 · PreprintImmunology