Author

Eddie A. James

Benaroya Research InstituteORCID 0000-0002-7217-5729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Jane Hoyt BuckneriD· 2 shared Ainara Castellanos–RubioiD· 1 shared Aïsha CallebautiD· 1 shared Anthony R. Jones· 1 shared Dieter BrömmeiD· 1 shared Eliot Mar· 1 shared Eric MeffreiD· 1 shared Eun Kyung SongiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

Jane Hoyt BucknerORCID

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 10, 2026

Cathepsin K Mediates the Formation of Potential Rheumatoid Arthritis-Relevant Cis- and Trans-Spliced Peptides Compatible With HLA-DR4 Presentation

Olivier Hinse, S. Yasin Tabatabaei Dakhili, Lee Freiburger…·Dieter Brömme

This study identifies cathepsin K-generated spliced peptides as potential autoantigens in RA, compatible with HLA-DR4 presentation.

DOI 10.64898/2026.09.06.749279

humanproteomics

ImmunologybioRxivPreprintDec 2, 2025

Long non-coding RNAs as a novel source of beta cell autoantigens in type 1 diabetes

Jon Mentxaka, Aïsha Callebaut, Koldo García‐Etxebarria…·Izortze Santín

This study identifies lncRNA-derived peptides that act as autoantigens in type 1 diabetes by activating CD4+ T cells through HLA-II restricted epitopes.

DOI 10.64898/2025.12.01.691527

humanproteomics

ImmunologybioRxivPreprintOct 14, 2025

Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis

Xiaohao Wu, Mengrui Zhang, Jae‐Seung Moon…·William H. Robinson

This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.

3 citations

Genetic & Genomic MedicineNature GeneticsPeer-reviewedMar 24, 2022

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Kazuyoshi Ishigaki, Kaitlyn A. Lagattuta, Yang Luo…·Soumya Raychaudhuri

The paper investigates how HLA alleles influence TCR CDR3 composition and finds strong associations between HLA risk alleles and specific CDR3 amino acid features linked to autoimmune diseases.

105 citationstop 1%

humanstatistical model