Development of a Novel CD4+ TCR Transgenic Line that Reveals a Dominant Role for CD8+ DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage Malaria
Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Ganchimeg Bayarsaikhan, Sanne H. Hendriks, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Tania F de Koning-Ward, , William R Heath
This paper develops a CD4+ TCR transgenic mouse line to study helper and CTL responses to blood-stage malaria, showing CD8+ DC and CD40-signaling are critical for immunity.
bioRxiv · Mar 3, 2017 · PreprintImmunology