Ashraful Haque

This study examines CD4+ T cell responses in visceral leishmaniasis using single-cell RNA sequencing, revealing transcriptional heterogeneity and regulatory mechanisms affecting immune function.

This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.

The paper investigates how immune responses to infection affect peripheral sympathetic neuron functions, finding that cytokines and interferons alter nerve growth and neuron excitability.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

The paper identifies CXCR6⁺ CD127⁻ Tr1 cells as key regulators in Plasmodium falciparum infection, showing they balance immunity and parasite persistence.

The paper shows that AIM assays overestimate Ag-specific CD4+ T cells due to TCR-independent activation and introduces a modified assay using CXCR4-CD137+ cells for accurate characterization.

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

This paper develops a CD4+ TCR transgenic mouse line to study helper and CTL responses to blood-stage malaria, showing CD8+ DC and CD40-signaling are critical for immunity.