MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis
Nachiyappan Venkatachalam, Li Wang, Niyumi Muthukumarana, Robert Ihnatko, Jeroen Krijgsveld, Olga Skabkina, Antonia Leipertz, Yubin Chen, Johannes Betge, Kim E. Boonekamp, Michael Boutros, Georg Stoecklin, Matthias P. Ebert, Johanna Schott, Tianzuo Zhan
This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.
bioRxiv · Jun 13, 2025 · PreprintCancer Biology