Kim E. Boonekamp

WNT-driven immune evasion promotes malignant transformation of BRAF-mutant colorectal cancer

This study shows that WNT signaling enables immune evasion in BRAF-mutant colorectal cancer, promoting tumor progression through changes in T cell phenotypes.

An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

Molecular recording of cellular protein kinase activity with chemical labeling

The paper introduces molecular recorders to track kinase activity in cells and applies them to study PKA activity and neuromodulation.

MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis

This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.

Shape stabilization in budding intestinal organoids by geometrical ratcheting

This study uses 3D reconstructions and simulations to show that geometrical ratcheting stabilizes the shape of budding intestinal organoids through changes in tension and actomyosin reorganization.

The drug-induced phenotypic landscape of colorectal cancer organoids

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.