Cancer BiologybioRxivPreprint
MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis
Nachiyappan Venkatachalam, Li Wang, Niyumi Muthukumarana…·Tianzuo Zhan
This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.
DOI 10.1101/2025.06.13.659446