RNA regulates repeat-associated non-AUG (RAN) translation initiation in C9orf72 FTD/ALS
Rosslyn Grosely, Shizuka B. Yamada, Antonio V. Puglisi, Michael Z. Palo, Carlos Alvarado, Christopher P. Lapointe, Aaron D. Gitler, Joseph Daniel Puglisi
This study investigates how RNA structure and sequence context influence RAN translation initiation in C9orf72 repeats, revealing a kinetic bottleneck in initiation at near-cognate start codons.
bioRxiv · Oct 9, 2025 · PreprintBiophysics