Author

Rosslyn Grosely

Stanford Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

Carlos AlvaradoiD· 3 shared Christopher P. LapointeiD· 3 shared Joseph Daniel PuglisiiD· 3 shared Michael Z. PaloiD· 2 shared Aaron D. GitleriD· 1 shared Adam MamotiD· 1 shared Ajinkya Dhepe· 1 shared Antonio V. Puglisi· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

Carlos AlvaradoORCID

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3 papers

Recent·Most cited

Remodeling of mRNA by eIF4F in human translation initiation

Carlos Alvarado, Christopher P. Lapointe, Jinfan Wang, Masaaki Sokabe, Rosslyn Grosely, Ajinkya Dhepe, Crystal I. Stackhouse, Michael Z. Palo, Adam Mamot, Jacek Jemielity, Christopher S. Fraser, Joseph Daniel Puglisi

This study uses single-molecule assays to show eIF4F binding and mRNA remodeling during translation initiation, revealing ATP-dependent conformational changes and their role in ribosome loading.

bioRxiv · Jun 19, 2026 · PreprintBiophysics

RNA regulates repeat-associated non-AUG (RAN) translation initiation in C9orf72 FTD/ALS

Rosslyn Grosely, Shizuka B. Yamada, Antonio V. Puglisi, Michael Z. Palo, Carlos Alvarado, Christopher P. Lapointe, Aaron D. Gitler, Joseph Daniel Puglisi

This study investigates how RNA structure and sequence context influence RAN translation initiation in C9orf72 repeats, revealing a kinetic bottleneck in initiation at near-cognate start codons.

bioRxiv · Oct 9, 2025 · PreprintBiophysics

eIF1 and eIF5 dynamically control translation start site fidelity

Rosslyn Grosely, Carlos Alvarado, Ivaylo P. Ivanov, Oliver B Nicholson, Joseph Daniel Puglisi, Thomas E. Dever, Christopher P. Lapointe

This study investigates how eIF1 and eIF5 dynamically regulate translation start site fidelity through single-molecule analysis and cell experiments.

Nature Structural & Molecular Biology · Jul 28, 2025Peer-reviewedBiophysics