Christopher P. Lapointe

This study uses single-molecule assays to show eIF4F binding and mRNA remodeling during translation initiation, revealing ATP-dependent conformational changes and their role in ribosome loading.

This study identifies a ribosomal kinetic checkpoint that governs selective mRNA recruitment through a branched pathway involving productive and arrested states.

The paper identifies a conformational switch in eIF5 that regulates translation initiation at AUG and non-AUG codons by stabilizing or destabilizing the initiation complex.

This study investigates how RNA structure and sequence context influence RAN translation initiation in C9orf72 repeats, revealing a kinetic bottleneck in initiation at near-cognate start codons.

This study investigates how eIF1 and eIF5 dynamically regulate translation start site fidelity through single-molecule analysis and cell experiments.

This study shows SARS-CoV-2 nsp1 inhibits translation in bat cells and human cells, revealing its broad activity across mammals.

This paper uses a deaminase-based RNA recording method to profile protein-RNA interactions by introducing nucleotide edits detectable via DNA sequencing, revealing conserved sequence requirements across different contexts.

This paper introduces a semi-permeable capsule for single-cell genome sequencing, enabling uniform coverage and minimal cross-contamination for detecting genomic variants.

The paper investigates the phenotypic consequences of RPS25 and RACK1 loss in human cells, finding that RPS25 knockout leads to irreversible resistance traits and gene expression rewiring.

The paper identifies RNA localization by covalently tagging RNAs near a uridine-adding enzyme anchored at specific subcellular sites, revealing conserved dual localization of RNAs across species.

The paper studies the architecture and dynamics of overlapping RNA regulatory networks involving Puf3p, Puf4p, and Puf5p in yeast, revealing how competition and abundance influence network behavior.