Carlos Alvarado

This study uses single-molecule assays to show eIF4F binding and mRNA remodeling during translation initiation, revealing ATP-dependent conformational changes and their role in ribosome loading.

This study identifies a ribosomal kinetic checkpoint that governs selective mRNA recruitment through a branched pathway involving productive and arrested states.

The paper defines an extended translation initiation sequence (eTIS) and shows that a deep-learning model trained on eTIS features accurately predicts translation initiation, revealing that the Kozak sequence is not optimal and identifying conserved nucleotides that enhance initiation efficiency.

This study investigates how RNA structure and sequence context influence RAN translation initiation in C9orf72 repeats, revealing a kinetic bottleneck in initiation at near-cognate start codons.

This study investigates how eIF1 and eIF5 dynamically regulate translation start site fidelity through single-molecule analysis and cell experiments.