Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels
Antony Lurie, Christina Alexandra Stephens, David M. Kern, Katharine M. Henn, Naomi R. Latorraca, Stephen Graf Brohawn
This study determines the structure of LRRC8A:D VRACs using cryo-EM, revealing lipid-gating and subunit-specific structural features.
Nature Communications · Dec 12, 2025Peer-reviewedBiophysics