Author

David M. Kern

QB3ORCID 0000-0001-8529-9045Unclaimed ORCID profile · follow to get notified of new preprints

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David M. Kern1 paper

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Stephen Graf BrohawniD· 2 shared Antony Lurie· 1 shared Christina Alexandra StephensiD· 1 shared Katharine M. HenniD· 1 shared Naomi R. LatorracaiD· 1 shared Richard K. HiteiD· 1 shared SeCheol OhiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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7 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

Stephen Graf BrohawnORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedDec 12, 2025

Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels

Antony Lurie, Christina Alexandra Stephens, David M. Kern…·Stephen Graf Brohawn

This study determines the structure of LRRC8A:D VRACs using cryo-EM, revealing lipid-gating and subunit-specific structural features.

10 citations

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NeuroscienceeLifePeer-reviewedFeb 18, 2019

Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

David M. Kern, SeCheol Oh, Richard K. Hite, Stephen Graf Brohawn

The paper presents cryo-EM structures of LRRC8A in lipid nanodiscs with DCPIB inhibitor, revealing gating mechanisms and lipid-dependent structural changes.

115 citationstop 3%

experimental assay

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