Emergence of disease-specific endothelial and stromal cell populations responsible for arterial remodeling during development of pulmonary arterial hypertension
Nicholas D Cober, Emma R. McCourt, Rafael Soares Godoy, Yupu Deng, Kenny Schlosser, Anu Situ, David P. Cook, Sarah-Eve S Lemay, Timothy M. Klouda, Ke Yuan, Sébastien Bonnet, Duncan John Stewart
The paper uses scRNA-seq to identify disease-specific endothelial and stromal cell populations involved in arterial remodeling in PAH, highlighting TM4SF1 as a potential therapeutic target.
bioRxiv · Sep 6, 2023 · PreprintMolecular Biology