Author

Timothy M. Klouda

Boston Children's HospitalORCID 0000-0002-8485-9773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Ke YuaniD· 3 shared Yunhye KimiD· 2 shared Anu Situ· 1 shared Benjamin A Raby· 1 shared Benjamin A. RabyiD· 1 shared David P. CookiD· 1 shared Duncan John StewartiD· 1 shared Emma R. McCourtiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Ke YuanORCID

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3 papers

Recent·Most cited

Specialized Pericyte Subtypes in the Pulmonary Capillary

Timothy M. Klouda, Yunhye Kim, Seung Han Baek, Mantu Bhaumik, Yu Liu, Jianwen Que, Joseph C. Wu, Benjamin A Raby, Ke Yuan

The paper identifies two specialized pericyte subtypes in pulmonary capillaries using Higd1b as a marker and shows their distinct functions and responses to hypoxia.

The EMBO Journal · Jan 13, 2025Peer-reviewedCell Biology

Smooth muscle Cxcl12 activation is associated with vascular remodeling in flow-induced pulmonary hypertension

Timothy M. Klouda, Savas T. Tsikis, Thomas I. Hirsch, Yunhye Kim, Tiffany Liu, Ingeborg Friehs, John Y.-J. Shyy, Gary A. Visner, Benjamin A. Raby, Mark Puder, Ke Yuan

The paper identifies smooth muscle Cxcl12 activation as a contributor to vascular remodeling in flow-induced pulmonary hypertension using a new murine model.

bioRxiv · Sep 10, 2024 · PreprintMolecular Biology

Emergence of disease-specific endothelial and stromal cell populations responsible for arterial remodeling during development of pulmonary arterial hypertension

Nicholas D Cober, Emma R. McCourt, Rafael Soares Godoy, Yupu Deng, Kenny Schlosser, Anu Situ, David P. Cook, Sarah-Eve S Lemay, Timothy M. Klouda, Ke Yuan, Sébastien Bonnet, Duncan John Stewart

The paper uses scRNA-seq to identify disease-specific endothelial and stromal cell populations involved in arterial remodeling in PAH, highlighting TM4SF1 as a potential therapeutic target.

bioRxiv · Sep 6, 2023 · PreprintMolecular Biology