Ke Yuan

This study identifies EBF1 as a regulator of embryonic artery formation and shows its reactivation in pulmonary arterial hypertension drives pathological vascular remodeling.

The paper identifies two specialized pericyte subtypes in pulmonary capillaries using Higd1b as a marker and shows their distinct functions and responses to hypoxia.

This study identifies LIFR as a master amplifier of fibroblast activation in IPF, showing that blocking LIFR reduces fibrosis in ex vivo tissue.

The paper identifies smooth muscle Cxcl12 activation as a contributor to vascular remodeling in flow-induced pulmonary hypertension using a new murine model.

The paper uses scRNA-seq to identify disease-specific endothelial and stromal cell populations involved in arterial remodeling in PAH, highlighting TM4SF1 as a potential therapeutic target.