H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition
Yupei Guo, Zian Li, Leslie A. Parsels, Zhuwen Wang, Joshua D. Parsels, Anushka Dalvi, Stephanie The, Nan Hu, Victoria M. Valvo, Robert E. Doherty, Erik R. Peterson, Xinjun Wang, Sujatha Venkataraman, Sameer Agnihotri, Sriram Venneti, , Qiang Zhang
This study shows H3K27M diffuse midline glioma is HRR defective and radiosensitized by PARP inhibitors, with enhanced NK cell-mediated immunity.
Neuro-Oncology · Apr 3, 2025Peer-reviewedCancer Biology