Stephanie The

Isolation and characterization of microbiota from human pancreatic tumors and small intestine

This study isolates and characterizes microbiota from human pancreatic tumors and small intestine, revealing how a Klebsiella oxytoca strain affects the tumor microenvironment and therapy response.

Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition

This study shows H3K27M diffuse midline glioma is HRR defective and radiosensitized by PARP inhibitors, with enhanced NK cell-mediated immunity.

Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cells

This study shows that intracellular C3d enhances immune surveillance by inducing T cell responses against malignant plasma cells while sparing normal cells in a murine model of multiple myeloma.