Skeletal muscle TDP-43 aggregation drives progressive motor dysfunction and neurodegeneration with potential for functional recovery after clearance
Shuzhao Zhuang, Nadia Hafizi Rastabi, Saeedeh Robatjazi, Anushka Podar, Angus Lindsay, Saba Gharibi, Felicity Dunlop, Jen Davis, Claire Laird, Adam K. Walker, Aaron Paul Russell
This study shows that TDP-43 aggregation in skeletal muscle causes motor dysfunction and neurodegeneration, but clearance of the protein allows for functional recovery.
bioRxiv · Jul 20, 2025 · PreprintNeuroscience