Felicity Dunlop

This paper develops and validates a SEC-SAX protocol for enriching extracellular vesicles from small plasma volumes for quantitative proteomics in human and mouse samples.

This study shows that TDP-43 aggregation in skeletal muscle causes motor dysfunction and neurodegeneration, but clearance of the protein allows for functional recovery.

The paper isolates and analyzes the proteome of TDP-43-associated insoluble stress granules in an ALS mouse model, identifying sustained stress granule formation, CLUH granule recruitment, and impaired mitochondrial metabolism.