Discovery of a molecular glue inhibitor that stabilises a non-productive Kalirin-Rac1 complex
Janine L. Gray, Mia C. Callens, Amelia Henley, Daniel Zaidman, Carmen Jimenez Antunez, Andrew P. Thompson, Zhihe Lei, R. Skyner, Michael Miller, Eleanor P. Williams, Anya Robinson, Raina Seupal, Matt T. Fry, Mihajlo Filep, F. von Delft, , Paul E. Brennan
The paper identifies covalent molecular glue inhibitors that stabilize a non-productive Kalirin-Rac1 complex, inhibiting nucleotide exchange and reducing GEF turnover.
bioRxiv · Sep 11, 2026 · PreprintBiochemistry