Annette von Delft

Discovery of a molecular glue inhibitor that stabilises a non-productive Kalirin-Rac1 complex

The paper identifies covalent molecular glue inhibitors that stabilize a non-productive Kalirin-Rac1 complex, inhibiting nucleotide exchange and reducing GEF turnover.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

Discovery of orally bioavailable Zika virus NS2B-NS3 protease inhibitors with efficacy in a murine infection model

The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor

This paper describes the optimization of a SARS-CoV-2 Mpro inhibitor to address genotoxic and metabolic liabilities, leading to improved in vivo efficacy and exposure.