MEA-LINK identifies the CCL4-CCR5 axis in neuronal hyperactivity control by human microglia
Annika Mordelt, Nicky Scheefhals, Imke M. E. Schuurmans, Koen Slottje, Mariela Cano Rivera, Marina P. Hommersom, Ao Huang, Leon Bichmann, Elly Lewerissa, Eline van Hugte, Dirk Schubert, John S. Tsang, Nael Nadif Kasri, Lot D. de Witte
MEA-LINK identifies CCL4-CCR5 signaling as a mechanism by which human microglia regulate neuronal hyperactivity through secreted factors and network activity.
bioRxiv · Feb 6, 2026 · PreprintNeuroscience