Author

Koen Slottje

Radboud University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Annika MordeltiD· 2 shared Dirk SchubertiD· 2 shared Imke M. E. SchuurmansiD· 2 shared Lot D. de WitteiD· 2 shared Marina P. HommersomiD· 2 shared Nael Nadif KasriiD· 2 shared Nicky ScheefhalsiD· 2 shared Ao Huang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Annika MordeltORCID

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2 papers

Recent·Most cited

MEA-LINK identifies the CCL4-CCR5 axis in neuronal hyperactivity control by human microglia

Annika Mordelt, Nicky Scheefhals, Imke M. E. Schuurmans, Koen Slottje, Mariela Cano Rivera, Marina P. Hommersom, Ao Huang, Leon Bichmann, Elly Lewerissa, Eline van Hugte, Dirk Schubert, John S. Tsang, Nael Nadif Kasri, Lot D. de Witte

MEA-LINK identifies CCL4-CCR5 signaling as a mechanism by which human microglia regulate neuronal hyperactivity through secreted factors and network activity.

bioRxiv · Feb 6, 2026 · PreprintNeuroscience

Long-term co-maturation of stem cell-derived microglia and neuronal networks: an optimized platform to assess human microglial contribution to neuronal function

Annika Mordelt, Imke M. E. Schuurmans, Nicky Scheefhals, Marina P. Hommersom, Koen Slottje, Kimberly Mast, Mara Graziani, Carlos O. González, Laura J. A. Wingens, Dirk Schubert, Nael Nadif Kasri, Lot D. de Witte

This paper develops a co-maturation protocol to study human microglia-neuron interactions using hiPSCs, showing astrocytes are needed for microglia survival and integration into neuronal networks.

bioRxiv · Oct 24, 2025 · PreprintNeuroscience