Annika Mordelt

Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network development

This study presents a one-step protocol to differentiate hiPSCs into functional astrocytes, enabling co-culture with neurons to support network development.

MEA-LINK identifies the CCL4-CCR5 axis in neuronal hyperactivity control by human microglia

MEA-LINK identifies CCL4-CCR5 signaling as a mechanism by which human microglia regulate neuronal hyperactivity through secreted factors and network activity.

Mapping NMD-coupled alternative splicing in iPSC-derived brain cells: a resource for therapeutic discovery

The paper maps NMD-coupled alternative splicing events in iPSC-derived brain cells and identifies therapeutic targets for neurodevelopmental disorders.

Long-term co-maturation of stem cell-derived microglia and neuronal networks: an optimized platform to assess human microglial contribution to neuronal function

This paper develops a co-maturation protocol to study human microglia-neuron interactions using hiPSCs, showing astrocytes are needed for microglia survival and integration into neuronal networks.

Human-Specific Regulation of CHD2 Controls the Tempo of Cortical Development through Lysosomal Homeostasis

This study identifies a human-specific CHD2 regulatory variant that influences cortical development tempo via lysosomal homeostasis, showing therapeutic potential through lysosomal restoration.

CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability

This study characterizes a human neuronal model of CACNA1A haploinsufficiency, revealing synaptic deficits and increased intrinsic excitability linked to reduced potassium channel function.

Neuronal autophagosomes are transported to astrocytes for degradation

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

This paper describes a humanized mouse model using iPSC-derived microglia to study HIV-1 infection in the CNS, enabling genetic and therapeutic investigations in vivo.