Developmental BiologybioRxivPreprint
The metaplastic precursor state to oesophageal adenocarcinoma represents reversion to a transient epithelial cell state in the developing oesophagus
Syed Murtuza Baker, Aoibheann F. Mullan, Rachel E. Jennings…·Andrew D Sharrocks
The paper identifies a metaplastic precursor state in Barrett's oesophagus as a reversion to a fetal epithelial cell state, revealing HNF4A's role and GWAS SNPs in regulatory regions.