Neil A. Hanley

This study presents a transcriptomic atlas of the developing human outflow tract and its adult aortic valve derivatives, revealing persistent embryonic signatures and key regulatory factors in valve development.

This study identifies HAND1's concentration-dependent role in specifying cardiac and extraembryonic progenitors from human pluripotent stem cells.

The paper identifies a metaplastic precursor state in Barrett's oesophagus as a reversion to a fetal epithelial cell state, revealing HNF4A's role and GWAS SNPs in regulatory regions.

The paper identifies homozygous loss of function variants in ZNF808 as a cause of pancreatic agenesis in humans, showing its role in repressing transposable elements during pancreatic development.

The paper identifies TEAD1 as a repressor of tissue-specific transcription factors in human organ development by analyzing combinatorial TF binding in enhancers.

The paper maps the spatial transcriptional changes in human liver cirrhosis, identifying gene signatures and cell state transitions linked to disease progression.

The paper improves the maturation of human pluripotent stem cell-derived hepatocytes using thyroid hormone and ALK5 inhibitor, enhancing markers of adult liver function.

The paper shows that cell proliferation in human embryonic stem cell-derived endodermal progenitors primes enhancer landscapes for organ-specific differentiation by modulating chromatin accessibility and enhancer decommissioning.

The paper demonstrates an alternative androgen biosynthesis pathway in human fetal females with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency, leading to virilization despite low circulating androgens.

The paper maps histone modifications across thirteen human tissues during organogenesis to understand gene regulation and link noncoding mutations to developmental disorders.