Andrew D Sharrocks

This study presents a transcriptomic atlas of the developing human outflow tract and its adult aortic valve derivatives, revealing persistent embryonic signatures and key regulatory factors in valve development.

This study identifies ARID1A's role in regulating FOXA1 and AP-2 transcription factors in lobular breast cancer, revealing a distinct regulatory network and potential implications for metastasis.

Spartan identifies spatial domains and variable genes by integrating spatial topology and activation signals in spatial transcriptomics data.

This study examines epigenome and transcriptome changes in KS1 iPSCs and neuronal differentiation stages, identifying altered H3K4 methylation and gene expression patterns.

This study identifies gene regulatory networks driving periderm formation in early skin development using single-cell multiome and spatial transcriptomics data.

The paper identifies enhancer elements in oesophageal adenocarcinoma using STARR-seq and shows their relevance in disease and response to therapy.

The paper identifies a metaplastic precursor state in Barrett's oesophagus as a reversion to a fetal epithelial cell state, revealing HNF4A's role and GWAS SNPs in regulatory regions.

The paper introduces intNMF, a scalable method for integrating single cell gene expression and chromatin accessibility data, showing improved efficiency and interpretability in analyzing biological systems.

The paper maps the spatial transcriptional changes in human liver cirrhosis, identifying gene signatures and cell state transitions linked to disease progression.

This paper identifies ZMYM2's role in regulating transposable element transcription through distinct co-regulatory complexes in human cells.

The paper investigates how acetylation dynamics affect gene activation, finding two distinct gene classes with opposing requirements for acetylation levels in their transcriptional response.

The paper maps histone modifications across thirteen human tissues during organogenesis to understand gene regulation and link noncoding mutations to developmental disorders.

This study identifies ZIC3 as a key regulator of the transition from naïve to primed pluripotency in mouse ESCs by analyzing open chromatin changes and transcriptional networks.

The paper introduces Scasat, a pipeline for analyzing single-cell ATAC-seq data, and shows it can identify cell types by analyzing open chromatin regions.