Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity
Shaoyu Tu, Yue Du, Wei Liang, X Xu, Jiahui Zou, Yanrong Yang, Chuhan Xiong, YJ Li, Meijun Jiang, Aotian Ouyang, Tong Chen, Meilin Jin, Huanchun Chen, Hongbo Zhou
This study identifies lactylation of the influenza virus polymerase acidic protein (PA) as a novel mechanism enhancing viral replication and pathogenicity through host enzymes ATAT1 and SIRT1.
bioRxiv · Jul 10, 2026 · PreprintMicrobiology