Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapy
Vivek Behera, Alexander Guzzetta, Hannah Giba, Ue-Yu Pen, Anna Di Lello, Bipul Pandey, Benjamin A. Doran, Alessandra Esposito, Apameh Pezeshk, Aliya Husain, Christine M. Bestvina, Justin Paul Kline, Marina C. Garassino, Arjun Raman
This study identifies conserved spatial structures in tumors that predict immune response, using a classification framework based on transcriptional covariation.
Cell Reports Medicine · Aug 28, 2026Peer-reviewedCancer Biology