Alexander Guzzetta

Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapy

This study identifies conserved spatial structures in tumors that predict immune response, using a classification framework based on transcriptional covariation.

Diet outperforms microbial transplant to drive microbiome recovery post-antibiotics

This study shows that a regular chow diet, not microbial transplant, enables rapid gut microbiome recovery after antibiotics in mice, and that diet is essential for effective fecal microbiota transplant.

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation

This study identifies a Hedgehog-FGF signaling axis critical for anterior mesoderm patterning during gastrulation using single-cell transcriptomics in Hh-deficient embryos.