Intragenic Transcription from Defective HIV Proviruses Triggers Interferon Responses in Myeloid Cells
Jonathan M. Kilroy, Aparna Deokar, Samantha D. Drinan, Juan I. Fuxman Bass, Manish Sagar, Suryaram Gummuluru, Andrew J. Henderson
This study shows defective HIV proviruses trigger type I interferon responses in myeloid cells through MDA5-dependent pathways, contributing to chronic inflammation in people with HIV.
Journal of Virology · Aug 10, 2026Peer-reviewedMicrobiology