Author

Aprem Zaya

University of the Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2

Frequent Co-Authors

Margaret M.P. PearceiD· 2 shared Gabrielle E Pisano· 1 shared Graham H. DavisiD· 1 shared Kirby M. DonnellyiD· 1 shared Liqun LuoiD· 1 shared Olivia R DeLorenzoiD· 1 shared Ron R. KopitoiD· 1 shared Wint M Thu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersNeuroscience

Margaret M.P. PearceORCID

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2 papers

Recent·Most cited

Impairment of the glial phagolysosomal system drives prion-like propagation in a Drosophila model of Huntington's disease

Graham H. Davis, Aprem Zaya, Margaret M.P. Pearce

This study shows that mutant huntingtin aggregates impair glial phagocytosis and phagolysosomal function in Drosophila, leading to prion-like propagation of aggregates and neurodegeneration.

Journal of Neuroscience · Apr 8, 2024Peer-reviewedNeuroscience

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

Kirby M. Donnelly, Olivia R DeLorenzo, Aprem Zaya, Gabrielle E Pisano, Wint M Thu, Liqun Luo, Ron R. Kopito, Margaret M.P. Pearce

The paper shows that mutant huntingtin aggregates spread between neurons via phagocytic glia in Drosophila, requiring the Draper receptor and synaptic dysfunction.

eLife · May 28, 2020Peer-reviewedNeuroscience