Liqun Luo

This study identifies the distinct roles of Rab5 and Rab11 in regulating neural circuit assembly through endosome-mediated trafficking.

Whole-brain axon tracing in 110 mouse brains divides raphe serotonin neurons into five projectomic groups, tied to transcriptome plus position and to dissociable behavioral effects of depletion.

This study identifies conserved and clade-specific hypothalamic cell types across vertebrates using single-cell transcriptomics, revealing conserved transcription factors and rewired regulatory linkages.

The paper shows that precise CA1 input topography shapes subicular spatial coding and network dynamics, while preserving single-cell tuning and impairing boundary vector coding and long-term stability.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

The paper identifies inverse expression of Ten3 and Lphn2 in the developing mouse brain and shows their expression patterns predict connectivity in neural circuits.

The paper shows how Ten3 and Lphn2 mediate target selection in extended hippocampal networks through attraction and repulsion mechanisms, enabling repeated circuit assembly strategies.

The paper introduces endocytome profiling to map cell-surface protein dynamics in developing olfactory receptor neurons, revealing how endocytosis regulates axon pruning and targeting.

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

This study identifies teneurin-3 and latrophilin-2 as key molecules in forming the somatotopic map in the mouse spinal cord, showing their role in neuronal connectivity and body localization.

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

The paper identifies two distinct serotonin neuron populations that regulate pup care behavior in female mice, showing how they switch function across reproductive stages.

This study shows that neural representations of hunger and thirst are distinct in neonatal mice before they can seek food and water separately, and these representations persist despite environmental changes.

The paper identifies CD72 as a regulator of microglial tiling through proteomic profiling and functional assays.

The paper shows that dimensionality reduction simplifies synaptic partner matching in the fly antennal lobe by reducing a 3D search problem to a 1D trajectory.

The paper shows that altering a combination of cell-surface proteins in Drosophila olfactory neurons can switch their synaptic connections to different projection neuron types, revealing a combinatorial code for circuit assembly.

The paper identifies three CSP pairs mediating repulsive interactions that prevent non-cognate synaptic connections in Drosophila olfactory circuits.

This paper introduces a sparse driver system for cell-type specific single-cell labeling and manipulation in Drosophila, enabling tunable sparsity and multi-color staining.

The paper examines how serotonin receptor agonists and antagonists affect mouse behavior and whole-brain neuronal activity, revealing relationships between behavioral changes and Fos expression patterns.

This study identifies the intracellular signaling pathway of teneurins in synaptic partner matching using Drosophila models.

The paper identifies embryonically active piriform cortex neurons in mice and shows they promote recurrent connectivity during development through enhanced synaptic interactions.

This paper introduces Expansion Spatial Transcriptomics to improve spatial resolution and capture efficiency in spatial transcriptomics by expanding tissue before transcriptome capture, demonstrated on mouse brain samples.

The paper presents an aging Drosophila cell atlas, identifies cell type-specific aging patterns, and shows ribosomal gene expression as a conserved aging predictor.

This study investigates how projection neurons in Drosophila establish wiring specificity in the olfactory map through lineage, birth order, and dynamic dendrite remodeling during development.

This study shows that Lphn2's role in axon targeting depends on context-specific G protein coupling and autoproteolytic cleavage.

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.