Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses
Kirby M. Donnelly, Olivia R DeLorenzo, Aprem Zaya, Gabrielle E Pisano, Wint M Thu, Liqun Luo, Ron R. Kopito, Margaret M.P. Pearce
The paper shows that mutant huntingtin aggregates spread between neurons via phagocytic glia in Drosophila, requiring the Draper receptor and synaptic dysfunction.
eLife · May 28, 2020Peer-reviewedNeuroscience